Unknown

Dataset Information

0

The role and regulation of Rab40b-Tks5 complex during invadopodia formation and cancer cell invasion.


ABSTRACT: Invadopodia formation and extracellular matrix degradation are key events during cancer cell invasion, yet little is known about mechanisms mediating these processes. Here, we report that Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion. We also identify Tks5 (also known as SH3PXD2A), a known Src kinase substrate, as a new Rab40b effector protein and show that Tks5 functions as a tether that mediates Rab40b-dependent targeting of transport vesicles containing MMP2 and MMP9 to the extending invadopodia. Importantly, we also demonstrate that Rab40b and Tks5 levels are regulated by known tumor suppressor microRNA miR-204. This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression.

SUBMITTER: Jacob A 

PROVIDER: S-EPMC5201011 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4083496 | biostudies-literature
| S-EPMC2909319 | biostudies-literature
| S-EPMC7480108 | biostudies-literature
| S-EPMC2810640 | biostudies-literature
2012-03-08 | E-GEOD-36047 | biostudies-arrayexpress
| S-EPMC7396792 | biostudies-literature
| S-EPMC3795337 | biostudies-literature
2012-03-08 | GSE36047 | GEO
| S-EPMC6368464 | biostudies-literature
| S-EPMC3566011 | biostudies-literature