Ontology highlight
ABSTRACT:
SUBMITTER: Augoff K
PROVIDER: S-EPMC7396792 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Annals of translational medicine 20200701 14
The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft-enriched membrane protrusions known as invadopodia or, more broadly, invadosomes. Invadopodia are specialized adhesive structures arising from ventral cell surface within cell-extracellular matrix (ECM) contacts and concentrate high proteolytic activities that allow cells to overcome the dense scaffold of local microenvironment, comprising a natural barrier to cell spreading. This degradative activity di ...[more]