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Invadopodia: clearing the way for cancer cell invasion.

ABSTRACT: The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft-enriched membrane protrusions known as invadopodia or, more broadly, invadosomes. Invadopodia are specialized adhesive structures arising from ventral cell surface within cell-extracellular matrix (ECM) contacts and concentrate high proteolytic activities that allow cells to overcome the dense scaffold of local microenvironment, comprising a natural barrier to cell spreading. This degradative activity distinguishes invadopodia from other adhesive structures like focal adhesions, lamellipodia or filopodia, and is believed to drive cancer progression.

SUBMITTER: Augoff K

PROVIDER: S-EPMC7396792 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Invadopodia: clearing the way for cancer cell invasion.

Augoff Katarzyna K Hryniewicz-Jankowska Anita A Tabola Renata R

Annals of translational medicine 20200701 14

The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft-enriched membrane protrusions known as invadopodia or, more broadly, invadosomes. Invadopodia are specialized adhesive structures arising from ventral cell surface within cell-extracellular matrix (ECM) contacts and concentrate high proteolytic activities that allow cells to overcome the dense scaffold of local microenvironment, comprising a natural barrier to cell spreading. This degradative activity di ...[more]

PMID: 32793746

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