Ontology highlight
ABSTRACT:
SUBMITTER: Muvarak NE
PROVIDER: S-EPMC5201166 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20161001 4
Poly (ADP-ribose) polymerase inhibitors (PARPis) are clinically effective predominantly for BRCA-mutant tumors. We introduce a mechanism-based strategy to enhance PARPi efficacy based on DNA damage-related binding between DNA methyltransferases (DNMTs) and PARP1. In acute myeloid leukemia (AML) and breast cancer cells, DNMT inhibitors (DNMTis) alone covalently bind DNMTs into DNA and increase PARP1 tightly bound into chromatin. Low doses of DNMTis plus PARPis, versus each drug alone, increase PA ...[more]