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Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors.

ABSTRACT: Monoclonal antibodies (mAbs) have become a successful therapeutic approach in cancer. However, some patients do not achieve long-term clinical benefit and most mAbs only exert modest effects as monotherapies. Therefore, combinations with chemotherapy are currently being investigated. Emerging studies have shown a synergistic therapeutic effect of PARP inhibitors and mAbs in cancer. PARP enzymes catalytically cleave ?-NAD+ and transfer the ADP-ribose moiety to acceptor proteins, modifying their function. In here, we update recent data about the therapeutic effect of the combination of PARP inhibitors with mAbs in cancer treatment and discuss the molecular mechanisms involved in this synergy.

SUBMITTER: Yelamos J

PROVIDER: S-EPMC4760278 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors.

Yélamos José J Galindo Miguel M Navarro Judith J Albanell Joan J Rovira Ana A Rojo Federico F Oliver Javier J

Oncoimmunology 20150701 1

Monoclonal antibodies (mAbs) have become a successful therapeutic approach in cancer. However, some patients do not achieve long-term clinical benefit and most mAbs only exert modest effects as monotherapies. Therefore, combinations with chemotherapy are currently being investigated. Emerging studies have shown a synergistic therapeutic effect of PARP inhibitors and mAbs in cancer. PARP enzymes catalytically cleave β-NAD<sup>+</sup> and transfer the ADP-ribose moiety to acceptor proteins, modify ...[more]

PMID: 26942084

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