Ontology highlight
ABSTRACT:
SUBMITTER: Koenecke N
PROVIDER: S-EPMC5204345 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Koenecke Nina N Johnston Jeff J He Qiye Q Meier Samuel S Zeitlinger Julia J
Genome research 20161114 1
Histone modifications are frequently used as markers for enhancer states, but how to interpret enhancer states in the context of embryonic development is not clear. The poised enhancer signature, involving H3K4me1 and low levels of H3K27ac, has been reported to mark inactive enhancers that are poised for future activation. However, future activation is not always observed, and alternative reasons for the widespread occurrence of this enhancer signature have not been investigated. By analyzing en ...[more]