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Brown and Beige Adipose Tissue: Therapy for Obesity and Its Comorbidities?


ABSTRACT: Overweight and obesity are global health problems placing an ever-increasing demand on health care systems. Brown adipose tissue (BAT) is present in significant amounts in adults. BAT has potential as a fuel for oxidation and dissipation as heat production, which makes it an attractive target for obesity therapy. BAT activation results in increased energy expenditure via thermogenesis. The role of BAT/beige adipocyte activation on whole body energy homeostasis, body weight management/regulation, and whole body glucose and lipid homeostasis remains unproven. This paper reviews knowledge on brown/beige adipocytes in energy expenditure and how it may impact obesity therapy and its comorbidities.

SUBMITTER: Mulya A 

PROVIDER: S-EPMC5206678 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Brown and Beige Adipose Tissue: Therapy for Obesity and Its Comorbidities?

Mulya Anny A   Kirwan John P JP  

Endocrinology and metabolism clinics of North America 20160901 3


Overweight and obesity are global health problems placing an ever-increasing demand on health care systems. Brown adipose tissue (BAT) is present in significant amounts in adults. BAT has potential as a fuel for oxidation and dissipation as heat production, which makes it an attractive target for obesity therapy. BAT activation results in increased energy expenditure via thermogenesis. The role of BAT/beige adipocyte activation on whole body energy homeostasis, body weight management/regulation,  ...[more]

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