Ontology highlight
ABSTRACT:
SUBMITTER: Klepac K
PROVIDER: S-EPMC4786868 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature communications 20160309
Brown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the Gq family, and inhibition of Gq signalling enhances differentiation of human and murine brown adipocytes. In contrast, activation of Gq signalling abrogates brown adipogenesis. We fu ...[more]