Ontology highlight
ABSTRACT:
SUBMITTER: Xue N
PROVIDER: S-EPMC5206721 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Xue Nina N Zhou Qin Q Ji Ming M Jin Jing J Lai Fangfang F Chen Ju J Zhang Mengtian M Jia Jing J Yang Huarong H Zhang Jie J Li Wenbin W Jiang Jiandong J Chen Xiaoguang X
Scientific reports 20170103
Glioblastoma is an aggressive tumor that is associated with distinctive infiltrating microglia/macrophages populations. Previous studies demonstrated that chlorogenic acid (5-caffeoylquinic acid, CHA), a phenolic compound with low molecular weight, has an anti-tumor effect in multiple malignant tumors. In the present study, we focused on the macrophage polarization to investigate the molecular mechanisms behind the anti-glioma response of CHA in vitro and in vivo. We found that CHA treatment inc ...[more]