Ontology highlight
ABSTRACT:
SUBMITTER: Kramer PF
PROVIDER: S-EPMC5207023 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kramer Paul F PF Williams John T JT
Cell reports 20161201 12
Synaptic transmission is mediated by ionotropic and metabotropic receptors that together regulate the rate and pattern of action potential firing. Metabotropic receptors can activate ion channels and modulate other receptors and channels. The present paper examines the interaction between group 1 mGluR-mediated calcium release from stores and GABA<sub>B</sub>/D2-mediated GIRK currents in rat dopamine neurons of the Substantia Nigra. Transient activation of mGluRs decreased the GIRK current evoke ...[more]