Ontology highlight
ABSTRACT:
SUBMITTER: Cao Y
PROVIDER: S-EPMC5207029 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20160504 26
Chimeric antigen receptor T (CAR-T) cells have demonstrated promising results against hematological malignancies, but have encountered significant challenges in translation to solid tumors. To overcome these hurdles, we have developed a switchable CAR-T cell platform in which the activity of the engineered cell is controlled by dosage of an antibody-based switch. Herein, we apply this approach to Her2-expressing breast cancers by engineering switch molecules through site-specific incorporation o ...[more]