Ontology highlight
ABSTRACT:
SUBMITTER: Bersani F
PROVIDER: S-EPMC5207039 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Bersani Francesca F Lingua Marcello Francesco MF Morena Deborah D Foglizzo Valentina V Miretti Silvia S Lanzetti Letizia L Carrà Giovanna G Morotti Alessandro A Ala Ugo U Provero Paolo P Chiarle Roberto R Singer Samuel S Ladanyi Marc M Tuschl Thomas T Ponzetto Carola C Taulli Riccardo R
Cancer research 20160828 20
Current therapeutic options for the pediatric cancer rhabdomyosarcoma have not improved significantly, especially for metastatic rhabdomyosarcoma. In the current work, we performed a deep miRNA profiling of the three major human rhabdomyosarcoma subtypes, along with cell lines and normal muscle, to identify novel molecular circuits with therapeutic potential. The signature we determined could discriminate rhabdomyosarcoma from muscle, revealing a subset of muscle-enriched miRNA (myomiR), includi ...[more]