Ontology highlight
ABSTRACT:
SUBMITTER: Lipi F
PROVIDER: S-EPMC5207382 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lipi Farhana F Chen Suxiang S Chakravarthy Madhuri M Rakesh Shilpa S Veedu Rakesh N RN
RNA biology 20161007 12
Nucleic acid aptamers are single-stranded DNA or RNA oligonucleotide sequences that bind to a specific target molecule with high affinity and specificity through their ability to adopt 3-dimensional structure in solution. Aptamers have huge potential as targeted therapeutics, diagnostics, delivery agents and as biosensors. However, aptamers composed of natural nucleotide monomers are quickly degraded in vivo and show poor pharmacodynamic properties. To overcome this, chemically-modified nucleic ...[more]