Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast.
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ABSTRACT:
SUBMITTER: Shao S
PROVIDER: S-EPMC5209247 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast.
Shao Shuai S Do Trang Nhu TN Razi Aida A Chitgupi Upendra U Geng Jumin J Alsop Richard J RJ Dzikovski Boris G BG Rheinstädter Maikel C MC Ortega Joaquin J Karttunen Mikko M Spernyak Joseph A JA Lovell Jonathan F JF
Small (Weinheim an der Bergstrasse, Germany) 20161014 1
Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo. ...[more]
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