Ontology highlight
ABSTRACT:
SUBMITTER: Sang Y
PROVIDER: S-EPMC5209733 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170104
U24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that the interaction between U24 and WW domains is important for endocytic recycling of T-cell receptors, but a cognate ligand was never identified. In this contribution, data was obtained from pull-downs, ITC, NMR and molecular dynamics simulations to show that a specific intera ...[more]