Ontology highlight
ABSTRACT:
SUBMITTER: Mufazalov IA
PROVIDER: S-EPMC5210124 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Mufazalov Ilgiz A IA Schelmbauer Carsten C Regen Tommy T Kuschmann Janina J Wanke Florian F Gabriel Laureen A LA Hauptmann Judith J Müller Werner W Pinteaux Emmanuel E Kurschus Florian C FC Waisman Ari A
The EMBO journal 20161108 1
Interleukin-1 (IL-1) is implicated in numerous pathologies, including multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the exact mechanism by which IL-1 is involved in the generation of pathogenic T cells and in disease development remains largely unknown. We found that following EAE induction, pertussis toxin administration leads to IL-1 receptor type 1 (IL-1R1)-dependent IL-1β expression by myeloid cells in the draining lymph nodes. This myeloid ...[more]