Ontology highlight
ABSTRACT:
SUBMITTER: Heldwein EE
PROVIDER: S-EPMC521094 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Heldwein Ekaterina E EE Macia Eric E Wang Jing J Yin Helen L HL Kirchhausen Tomas T Harrison Stephen C SC
Proceedings of the National Academy of Sciences of the United States of America 20040917 39
The heterotetrameric adaptor proteins (AP complexes) link the outer lattice of clathrin-coated vesicles with membrane-anchored cargo molecules. We report the crystal structure of the core of the AP-1 complex, which functions in the trans-Golgi network (TGN). Packing of complexes in the crystal generates an exceptionally long (1,135-A) unit-cell axis, but the 6-fold noncrystallographic redundancy yields an excellent map at 4-A resolution. The AP-1 core comprises N-terminal fragments of the two la ...[more]