Ontology highlight
ABSTRACT:
SUBMITTER: Li P
PROVIDER: S-EPMC5266526 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Li Pengpeng P Merrill Sean A SA Jorgensen Erik M EM Shen Kang K
Neuron 20160501 3
The cardinal feature of neuronal polarization is the establishment and maintenance of axons and dendrites. How axonal and dendritic proteins are sorted and targeted to different compartments is poorly understood. Here, we identified distinct dileucine motifs that are necessary and sufficient to target transmembrane proteins to either the axon or the dendrite through direct interactions with the clathrin-associated adaptor protein complexes (APs) in C. elegans. Axonal targeting requires AP-3, whi ...[more]