Unknown

Dataset Information

0

Iridium-Catalyzed Regio- and Enantioselective Allylic Substitution of Trisubstituted Allylic Electrophiles.

ABSTRACT: The first Ir-catalyzed enantioselective allylation of trisubstituted allylic electrophiles has been developed. Through modification of the leaving group of allylic electrophiles, we found that trisubstituted allylic phosphates are suitable electrophiles for asymmetric allylation. The reaction of allylic phosphates with enol silanes derived from dioxinones gave allylated products in good yields with high enantioselectivities.

SUBMITTER: Chen M 

PROVIDER: S-EPMC5213737 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Iridium-Catalyzed Regio- and Enantioselective Allylic Substitution of Trisubstituted Allylic Electrophiles.

Chen Ming M   Hartwig John F JF  

Angewandte Chemie (International ed. in English) 20160817 38

The first Ir-catalyzed enantioselective allylation of trisubstituted allylic electrophiles has been developed. Through modification of the leaving group of allylic electrophiles, we found that trisubstituted allylic phosphates are suitable electrophiles for asymmetric allylation. The reaction of allylic phosphates with enol silanes derived from dioxinones gave allylated products in good yields with high enantioselectivities. ...[more]

Similar Datasets

Unknown Iridium-catalyzed, regio- and enantioselective allylic substitution with aromatic and aliphatic sulfinates.
| S-EPMC2802463 | biostudies-other
Unknown Iridium-catalyzed regio- and enantioselective allylic substitution of silyl dienolates derived from dioxinones.
| S-EPMC4214550 | biostudies-literature
Unknown Iridium-catalyzed enantioselective allylic substitution of unstabilized enolates derived from ?,?-unsaturated ketones.
| S-EPMC4159307 | biostudies-literature
Unknown The allyl intermediate in regioselective and enantioselective iridium-catalyzed asymmetric allylic substitution reactions.
| S-EPMC2814332 | biostudies-literature
Unknown Iridium-Catalyzed Enantioselective Allylic Substitution of Enol Silanes from Vinylogous Esters and Amides.
| S-EPMC5342901 | biostudies-literature
Unknown Highly Enantioselective Iridium-Catalyzed Hydrogenation of Conjugated Trisubstituted Enones.
| S-EPMC7884017 | biostudies-literature
Unknown Origins of Regioselectivity in Iridium Catalyzed Allylic Substitution.
| S-EPMC4699445 | biostudies-literature
Unknown Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates.
| S-EPMC5677530 | biostudies-literature
Unknown Regioselective molybdenum-catalyzed allylic substitution of tertiary allylic electrophiles: methodology development and applications.
| S-EPMC8159339 | biostudies-literature
Unknown Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins.
| S-EPMC6050583 | biostudies-literature