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Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata.

ABSTRACT: The isolation, structure determination, and biological activities of a new linear pentapeptide, caldoramide (5), from the marine cyanobacterium Caldora penicillata from Florida are described. Caldoramide (5) has structural similarities to belamide A (4), dolastatin 10 (1), and dolastatin 15 (2). We profiled caldoramide against parental HCT116 colorectal cancer cells and isogenic cells lacking oncogenic KRAS or hypoxia-inducible factors 1? (HIF-1?) and 2? (HIF-2?). Caldoramide (5) showed differential cytotoxicity for cells containing both oncogenic KRAS and HIF over the corresponding knockout cells. LCMS dereplication indicated the presence of caldoramide (5) in a subset of C. penicillata samples.

SUBMITTER: Gunasekera SP

PROVIDER: S-EPMC5215049 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata.

Gunasekera Sarath P SP Imperial Lorelie L Garst Christiana C Ratnayake Ranjala R Dang Long H LH Paul Valerie J VJ Luesch Hendrik H

Journal of natural products 20160705 7

The isolation, structure determination, and biological activities of a new linear pentapeptide, caldoramide (5), from the marine cyanobacterium Caldora penicillata from Florida are described. Caldoramide (5) has structural similarities to belamide A (4), dolastatin 10 (1), and dolastatin 15 (2). We profiled caldoramide against parental HCT116 colorectal cancer cells and isogenic cells lacking oncogenic KRAS or hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α). Caldoramide (5) showed differen ...[more]

PMID: 27380142

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