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Three New Malyngamides from the Marine Cyanobacterium Moorea producens.


ABSTRACT: Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).

SUBMITTER: Sueyoshi K 

PROVIDER: S-EPMC5742827 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Three New Malyngamides from the Marine Cyanobacterium Moorea producens.

Sueyoshi Kosuke K   Yamano Aki A   Ozaki Kaori K   Sumimoto Shimpei S   Iwasaki Arihiro A   Suenaga Kiyotake K   Teruya Toshiaki T  

Marine drugs 20171129 12


Three new compounds of the malyngamide series, 6,8-di-<i>O</i>-acetylmalyngamide 2 (<b>1</b>), 6-<i>O</i>-acetylmalyngamide 2 (<b>2</b>), and <i>N</i>-demethyl-isomalyngamide I (<b>3</b>), were isolated from the marine cyanobacterium <i>Moorea producens</i>. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-<i>O</i>-acetylmalyngamide 2 (<b>1</b>) showed p  ...[more]

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