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Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.

ABSTRACT: Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P?

SUBMITTER: Klaassens BL

PROVIDER: S-EPMC5215384 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.

Klaassens Bernadet L BL Rombouts Serge A R B SA Winkler Anderson M AM van Gorsel Helene C HC van der Grond Jeroen J van Gerven Joop M A JM

Human brain mapping 20160913 1

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired ...[more]

PMID: 27622387

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