Unknown

Dataset Information

0

Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic Escherichia coli.


ABSTRACT: This study aims to investigate the effects of dietary chitosan (COS) on gastrointestinal pathogen resistance in mice model. For two weeks, a control group of ICR mice received a basal diet whilst the intervention group received the basal diet supplemented with 300?mg/kg COS. After two weeks, the mice fed the supplemented diet had a lower body weight. Then enterotoxigenic Escherichia coli (E. coli) was administered to the mice through oral gavage, with each mouse receiving 108?CFU. At day 7 after infection, the bacterial load in the jejunum and faeces was significantly lower in the COS group than that in the control group. Moreover, the mRNA and protein levels of IL-1?, IL-6, IL-17, IL-18, and TNF-? were significantly lower in the group of mice receiving the COS diet; also the jejunal production of toll-like receptor-4 (TLR-4) was suppressed in the COS group. These results indicate the intervention influenced inflammation and controlled E. coli infection.

SUBMITTER: Liu G 

PROVIDER: S-EPMC5215628 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications

Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic <i>Escherichia coli</i>.

Liu Gang G   Chen Shuai S   Guan Guiping G   Tan Jun J   Al-Dhabi Naif A NA   Wang Hongbing H   Duraipandiyan Veeramuthu V   Fang Jun J  

Mediators of inflammation 20161222


This study aims to investigate the effects of dietary chitosan (COS) on gastrointestinal pathogen resistance in mice model. For two weeks, a control group of ICR mice received a basal diet whilst the intervention group received the basal diet supplemented with 300 mg/kg COS. After two weeks, the mice fed the supplemented diet had a lower body weight. Then enterotoxigenic <i>Escherichia coli</i> (<i>E. coli</i>) was administered to the mice through oral gavage, with each mouse receiving 10<sup>8<  ...[more]

Similar Datasets

| S-EPMC2897383 | biostudies-literature
| S-EPMC4121323 | biostudies-literature
| S-EPMC2095642 | biostudies-literature
| S-EPMC7555725 | biostudies-literature
| S-EPMC6192177 | biostudies-literature
| S-EPMC4582649 | biostudies-literature
| S-EPMC3472312 | biostudies-literature
| S-EPMC2916599 | biostudies-literature
| S-EPMC9264548 | biostudies-literature
| S-EPMC4860632 | biostudies-literature