Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5216128 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Liu Xiangyu X Shao Zhengping Z Jiang Wenxia W Lee Brian J BJ Zha Shan S
Nature communications 20170104
Non-homologous end-joining (NHEJ) is the most prominent DNA double strand break (DSB) repair pathway in mammalian cells. PAXX is the newest NHEJ factor, which shares structural similarity with known NHEJ factors-XRCC4 and XLF. Here we report that PAXX is dispensable for physiological NHEJ in otherwise wild-type mice. Yet Paxx<sup>-/-</sup> mice require XLF and Xlf<sup>-/-</sup> mice require PAXX for end-ligation. As such, Xlf<sup>-/-</sup>Paxx<sup>-/-</sup> mice display severe genomic instabilit ...[more]