Ontology highlight
ABSTRACT:
SUBMITTER: Kothari P
PROVIDER: S-EPMC5216390 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kothari P P De B P BP He B B Chen A A Chiuchiolo M J MJ Kim D D Nikolopoulou A A Amor-Coarasa A A Dyke J P JP Voss H U HU Kaminsky S M SM Foley C P CP Vallabhajosula S S Hu B B DiMagno S G SG Sondhi D D Crystal R G RG Babich J W JW Ballon D D
Scientific reports 20170106
Viral vector mediated gene therapy has become commonplace in clinical trials for a wide range of inherited disorders. Successful gene transfer depends on a number of factors, of which tissue tropism is among the most important. To date, definitive mapping of the spatial and temporal distribution of viral vectors in vivo has generally required postmortem examination of tissue. Here we present two methods for radiolabeling adeno-associated virus (AAV), one of the most commonly used viral vectors f ...[more]