Ontology highlight
ABSTRACT:
SUBMITTER: Brady JM
PROVIDER: S-EPMC5300685 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Immunological reviews 20170101 1
Broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) show great promise in HIV prevention as they are capable of potently neutralizing a considerable breadth of genetically diverse strains. Passive transfer of monoclonal bNAb proteins can confer protection in animal models of HIV infection at modest concentrations, inspiring efforts to develop an HIV vaccine capable of eliciting bNAb responses. However, these antibodies demonstrate high degrees of somatic mutation a ...[more]