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Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.

ABSTRACT: Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

SUBMITTER: Luo X

PROVIDER: S-EPMC5216453 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.

Luo X X Wang W W Dorkin J R JR Veiseh O O Chang P H PH Abutbul-Ionita I I Danino D D Langer R R Anderson D G DG Dong Y Y

Biomaterials science 20161201 1

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously. ...[more]

PMID: 27921096

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