Ontology highlight
ABSTRACT:
SUBMITTER: Kriegs M
PROVIDER: S-EPMC5216710 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kriegs Malte M Kasten-Pisula Ulla U Riepen Britta B Hoffer Konstantin K Struve Nina N Myllynen Laura L Braig Friederike F Binder Mascha M Rieckmann Thorsten T Grénman Reidar R Petersen Cordula C Dikomey Ekkehard E Rothkamm Kai K
Oncotarget 20160701 29
The increase in cellular radiosensitivity by EGF receptor (EGFR) inhibition has been shown to be attributable to the induction of a G1-arrest in p53-proficient cells. Because EGFR targeting in combination with radiotherapy is used to treat head and neck squamous cell carcinomas (HNSCC) which are predominantly p53 mutated, we tested the effects of EGFR targeting on cellular radiosensitivity, proliferation, apoptosis, DNA repair and cell cycle control using a large panel of HNSCC cell lines. In th ...[more]