Ontology highlight
ABSTRACT:
SUBMITTER: Belchis DA
PROVIDER: S-EPMC5216719 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Belchis Deborah A DA Tseng Li-Hui LH Gniadek Thomas T Haley Lisa L Lokhandwala Parvez P Illei Peter P Gocke Christopher D CD Forde Patrick P Brahmer Julie J Askin Frederic B FB Eshleman James R JR Lin Ming-Tseh MT
Oncotarget 20160701 29
EGFR-mutated lung adenocarcinomas routinely develop resistance to tyrosine kinase inhibitors (TKI). To better characterize the relative frequencies of the resistance mechanisms, we analyzed 48 EGFR-mutated TKI-resistant specimens from 41 patients. Next-generation sequencing of post-treatment specimens detected EGFR p.T790M in 31 (79%) of 39 patients, PIK3CA mutations in 10 (26%), EGFR p.S768_V769delinsIL in one, and KRAS p.G12C in one. Five PIK3CA mutations were outside of codons 542, 545, and 1 ...[more]