Ontology highlight
ABSTRACT:
SUBMITTER: Ryu D
PROVIDER: S-EPMC5216929 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Oncotarget 20160701 30
Immunoglobulin M multiple myeloma (IgM MM) is an extremely rare subtype of multiple myeloma with a poor clinical outcome. In this study, bone marrow aspirates of MM patients, including two cases of IgM MM, were analyzed by whole exome sequencing and RNA sequencing. Recurrent somatic mutations in the NRAS, KRAS, CCND1, DIS3, and TP53 genes were found in IgM MM and other types of MM, in agreement with previous studies. Overall transcription profiles of IgM and other types of MM clustered together, ...[more]