Targeted inhibition in tumors with ALK dependency.
Ontology highlight
ABSTRACT:
SUBMITTER: Kwak EL
PROVIDER: S-EPMC5217435 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Targeted inhibition in tumors with ALK dependency.
Kwak Eunice L EL Clark Jeffrey W JW Shaw Alice T AT
Lung Cancer (Auckland, N.Z.) 20130109
The oncogenic function of gene translocations involving the anaplastic lymphoma kinase (<i>ALK</i>) was first reported in rare subtypes of non-Hodgkin's lymphoma almost two decades ago. More recently, aberrant ALK signaling was found to be an oncogenic driver in subsets of non-small cell lung cancer (NSCLC), particularly in patients with little or no tobacco smoking history. The advent of molecularly targeted therapies that inhibit ALK has allowed the pairing of ALK inhibitors such as crizotinib ...[more]
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