Ontology highlight
ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC5217531 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Zeng Xianke X Willi Michaela M Shin Ha Youn HY Hennighausen Lothar L Wang Chaochen C
Cell reports 20161201 12
STAT5, a member of the family of signal transducers and activators of transcription, senses cytokines and controls the biology of cell lineages, including mammary, liver, and T cells. Here, we show that STAT5 activates lineage-specific and widely expressed genes through different mechanisms. STAT5 preferentially binds to promoter sequences of cytokine-responsive genes expressed across cell types and to putative enhancers of lineage-specific genes. While chromatin accessibility of STAT5-based enh ...[more]