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Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups.


ABSTRACT: Little is known about the association of the single nucleotide polymorphism (SNP) of rs364585 near serine palmitoyl-transferase long-chain base subunit 3 gene (SPTLC3) and serum lipid profiles. The present study was detected the association of the SPTLC3 rs364585 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations.Genotyping of the SPTLC3 rs364585 SNP was performed in 824 unrelated individuals of Han and 783 participants of Jing by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.There was no significant difference in either genotypic or allelic frequencies between Han and Jing, or between males and females of the both ethnic groups. The levels of serum low-density lipoprotein cholesterol (LDL-C) and the ratio of apolipoprotein (Apo) A1 to ApoB in Han; and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and LDL-C in Jing were different between the A allele carriers and the A allele non-carriers (P?

SUBMITTER: Zhang QH 

PROVIDER: S-EPMC5217591 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups.

Zhang Qing-Hui QH   Yin Rui-Xing RX   Gao Hui H   Huang Feng F   Wu Jin-Zhen JZ   Pan Shang-Ling SL   Lin Wei-Xiong WX   Yang De-Zhai DZ  

Lipids in health and disease 20170105 1


<h4>Background</h4>Little is known about the association of the single nucleotide polymorphism (SNP) of rs364585 near serine palmitoyl-transferase long-chain base subunit 3 gene (SPTLC3) and serum lipid profiles. The present study was detected the association of the SPTLC3 rs364585 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations.<h4>Methods</h4>Genotyping of the SPTLC3 rs364585 SNP was performed in 824 unrelated individuals of Han and 783 participa  ...[more]

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