Dataset Information

Association of RBM5 rs2013208 SNP with serum lipid levels in two Chinese ethnic groups.

ABSTRACT: The RNA binding motif protein 5 gene (RBM5) rs2013208 single nucleotide polymorphism (SNP) has been associated with high-density lipoprotein cholesterol (HDL-C) levels in a previous genome-wide association study, but little is known about such association of the RBM5 rs2013208 SNP and serum lipid profiles in the Chinese populations. The present study was to detect the association of the RBM5 rs2013208 SNP and several environmental factors with serum lipid levels in the Jing and Han populations. Genotyping of the RBM5 rs2013208 SNP in 635 subjects of Jing and 648 participants of Han peoples was performed by polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing. There were no significant differences in the genotypic and allelic frequencies of the RBM5 rs2013208 SNP between the two ethnic groups or between males and females. The RBM5 rs2013208G allele carriers had lower serum HDL-C levels in both Jing and Han than the G allele non-carriers. The G allele carriers in Jing had higher serum total cholesterol (TC) levels and higher apolipoprotein (Apo) A1/ApoB ratio than the G allele non-carriers (P < 0.05). Subgroup analysis according to sex showed that the G allele carriers had lower serum HDL-C levels in both Jing and Han females but not in males (P < 0.05). The G allele carriers had higher TC levels in Jing females but not in Jing males, and lower ApoA1/ApoB ratio in Jing males but not in Jing females. Serum lipid parameters were also correlated with several environmental factors in the Jing and Han populations, or in males and females in both ethnic groups. The association of the RBM5 rs2013208 SNP and serum lipid levels is different between the Jing and Han populations. These associations might have an ethnic- and/or sex-specificity.

SUBMITTER: Gao H

PROVIDER: S-EPMC6965480 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Association of RBM5 rs2013208 SNP with serum lipid levels in two Chinese ethnic groups.

Gao Hui H Yin Rui-Xing RX Zhang Qing-Hui QH Li Wei-Jun WJ Huang Jian-Hua JH Bin Yuan Y

International journal of clinical and experimental pathology 20170801 8

The RNA binding motif protein 5 gene (RBM5) rs2013208 single nucleotide polymorphism (SNP) has been associated with high-density lipoprotein cholesterol (HDL-C) levels in a previous genome-wide association study, but little is known about such association of the RBM5 rs2013208 SNP and serum lipid profiles in the Chinese populations. The present study was to detect the association of the RBM5 rs2013208 SNP and several environmental factors with serum lipid levels in the Jing ...[more]

PMID: 31966706

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Project description:Little is known about the association of the single nucleotide polymorphism (SNP) of rs2929282 near the FERM domain containing 5 (FRMD5) and serum lipid profiles. The present study detected the association of the FRMD5 rs2929282 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations. Genotyping of the FRMD5 rs2929282 SNP in 1065 subjects of Jing and 1061 participants of Han peoples was performed by polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing. The genotypic and allelic frequencies of the SNP were different between Han and Jing (P < 0.05). The frequency of the T allele was higher in Han than in Jing (8.2% vs. 6.1%). The genotypic and allelic frequencies of the FRMD5 rs2929282 SNP were significantly different between Han males and females (P < 0.05 for each), but not between Jing males and females. The frequency of the T allele was higher in Han females than in Han males (9.3% vs. 6.5%). The FRMD5 rs2929282 T allele carriers had lower serum high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1, and ApoB levels, and higher triglyceride (TG) levels in Jing but not in Han than the T allele non-carriers. Subgroup analysis according to sex showed that the T allele carriers had higher serum TG levels in Jing females but not in males than the T allele non-carriers (P < 0.05). The T allele carriers had higher HDL-C levels in Han males but not in Han females, and lower HDL-C levels in Jing females but not in Jing males compared to the T allele non-carriers (P < 0.05). The T allele carriers had lower ApoA1 levels in Jing females but not in Jing males and lower ApoB levels in Jing males but not in Jing females than the T allele non-carriers (P < 0.05). Serum lipid traits were also associated with several environmental factors in the Han and Jing populations, and in males and females of the both ethnic groups. These findings indicated that there may be a racial/ethnic- and/or sex-specific association of the FRMD5 rs2929282 SNP and serum lipid levels.

Project description:BackgroundNiemann-pick C1-like 1 (NPC1L1) is a key protein for intestinal cholesterol transportation. Common single nucleotide polymorphisms (SNPs) in the NPC1L1 gene have been associated with cholesterol absorption and serum lipid levels. The present study was undertaken to explore the possible association of NPC1L1 rs2072183 1735 C > G SNP and several environmental factors with serum lipid levels in the Mulao and Han populations.MethodsGenotyping of the rs2072183 SNP was performed in 688 subjects of Mulao and 738 participants of Han Chinese. The interactions between NPC1L1 1735 C > G polymorphism and several environmental factors on serum lipid phenotypes were tested using the factorial design covariance analysis after controlling for potential confounders.ResultsThe frequency of G allele was lower in Mulao than in Han (29.72% vs. 37.26%, P < 0.001). The frequency of CC, CG and GG genotypes was 49.85%, 40.84% and 9.31% in Mulao, and 39.30%, 46.88% and 13.82% in Han (P < 0.001); respectively. The levels of low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) B and the ratio of ApoAI/ApoB in Han but not in Mulao were different among the three genotypes (P < 0.05 for all), the subjects with GG and CG genotypes had higher LDL-C, ApoB levels and lower ApoAI/ApoB ratio than the subjects with CC genotype. Subgroup analysis showed that the G allele carriers in Han had higher total cholesterol (TC), LDL-C and ApoB levels in males (P < 0.05) and lower ApoAI/ApoB ratio in both sexes (P < 0.05) than the G allele noncarriers. The G allele carriers in Mulao had higher TC and LDL-C levels in males (P < 0.05) and lower high-density lipoprotein cholesterol (HDL-C) levels in both sexes (P < 0.05) than the G allele noncarriers. Serum TC, LDL-C, ApoB levels and ApoAI/ApoB ratio were correlated with genotypes in Han males (P < 0.05) but not in females. Serum lipid parameters were also correlated with several environmental factors. The genotypes of rs2072183 SNP were interacted with gender or cigarette smoking to influence serum TC and HDL-C levels in Mulao, whereas the genotypes of rs2072183 SNP were interacted with several environmental factors to influence all seven lipid traits in Han (P < 0.05-0.01).ConclusionsThe present study suggests that the rs2072183 SNP in NPC1L1 gene and its association with serum lipid profiles are different between the Mulao and Han populations. The difference in serum lipid profiles between the two ethnic groups might partly result from different rs2072183 SNP or NPC1L1 gene-environmental interactions.

Dataset Information

Association of RBM5 rs2013208 SNP with serum lipid levels in two Chinese ethnic groups.

Publications

Association of <i>RBM5</i> rs2013208 SNP with serum lipid levels in two Chinese ethnic groups.

Similar Datasets

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