Unknown

Dataset Information

0

A transcription factor hierarchy defines an environmental stress response network.


ABSTRACT: Environmental stresses are universally encountered by microbes, plants, and animals. Yet systematic studies of stress-responsive transcription factor (TF) networks in multicellular organisms have been limited. The phytohormone abscisic acid (ABA) influences the expression of thousands of genes, allowing us to characterize complex stress-responsive regulatory networks. Using chromatin immunoprecipitation sequencing, we identified genome-wide targets of 21 ABA-related TFs to construct a comprehensive regulatory network in Arabidopsis thaliana Determinants of dynamic TF binding and a hierarchy among TFs were defined, illuminating the relationship between differential gene expression patterns and ABA pathway feedback regulation. By extrapolating regulatory characteristics of observed canonical ABA pathway components, we identified a new family of transcriptional regulators modulating ABA and salt responsiveness and demonstrated their utility to modulate plant resilience to osmotic stress.

SUBMITTER: Song L 

PROVIDER: S-EPMC5217750 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

A transcription factor hierarchy defines an environmental stress response network.

Song Liang L   Huang Shao-Shan Carol SC   Wise Aaron A   Castanon Rosa R   Nery Joseph R JR   Chen Huaming H   Watanabe Marina M   Thomas Jerushah J   Bar-Joseph Ziv Z   Ecker Joseph R JR  

Science (New York, N.Y.) 20161101 6312


Environmental stresses are universally encountered by microbes, plants, and animals. Yet systematic studies of stress-responsive transcription factor (TF) networks in multicellular organisms have been limited. The phytohormone abscisic acid (ABA) influences the expression of thousands of genes, allowing us to characterize complex stress-responsive regulatory networks. Using chromatin immunoprecipitation sequencing, we identified genome-wide targets of 21 ABA-related TFs to construct a comprehens  ...[more]

Similar Datasets

| S-EPMC5745077 | biostudies-literature
| S-EPMC2571009 | biostudies-literature
| S-EPMC8287911 | biostudies-literature
| S-EPMC9006079 | biostudies-literature
| S-EPMC3584220 | biostudies-literature
| S-EPMC10482368 | biostudies-literature
| S-EPMC2610386 | biostudies-literature
| S-EPMC1838485 | biostudies-literature
| S-EPMC3677443 | biostudies-literature
| S-EPMC3186425 | biostudies-literature