Ontology highlight
ABSTRACT:
SUBMITTER: Yang XH
PROVIDER: S-EPMC5745077 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Yang Xinan H XH Nadadur Rangarajan D RD Hilvering Catharina Re CR Bianchi Valerio V Werner Michael M Mazurek Stefan R SR Gadek Margaret M Shen Kaitlyn M KM Goldman Joseph Aaron JA Tyan Leonid L Bekeny Jenna J Hall Johnathon M JM Lee Nutishia N Perez-Cervantes Carlos C Burnicka-Turek Ozanna O Poss Kenneth D KD Weber Christopher R CR de Laat Wouter W Ruthenburg Alexander J AJ Moskowitz Ivan P IP
eLife 20171227
The noncoding genome is pervasively transcribed. Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a general facet of enhancer function and some have been shown to be required for enhancer activity. Here we examine the transcription-factor-(TF)-dependence of ncRNA expression to define enhancers and enhancer-associated ncRNAs that are involved in a TF-dependent regulatory network. TBX5, a cardiac TF, regulates a network of cardiac channel genes to maintain cardiac rhythm. We ...[more]