Investigation of sinonasal microbiome spatial organization in chronic rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is a multifactorial inflammatory airway disorder in which bacteria are implicated in the initiation and/or sustenance of disease in some patients. The sinuses are colonized by bacteria even in health, and the potential for sinus-specific niches harboring unique microbial consortia raises questions for clinical and research investigation. The objective was to determine the degree to which resident upper airways microbiota differ between individuals and anatomic sites, in order to determine the optimal site of microbial sampling for study in CRS.

Methods

Eight CRS patients undergoing primary surgery were sampled bilaterally at the anterior nares, middle meatus, nasopharynx, maxillary sinus, frontal sinus, and sphenoid sinus for investiga

SUBMITTER: Ramakrishnan VR 

PROVIDER: S-EPMC5218946 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature