SHARPIN Facilitates p53 Degradation in Breast Cancer Cells.
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ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5219588 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
SHARPIN Facilitates p53 Degradation in Breast Cancer Cells.
Yang Huijie H Yang Huijie H Yu Sifan S Wang Weilong W Li Xin X Hou Yingxiang Y Liu Zhenhua Z Shi Yuanyuan Y Mu Kun K Niu Gang G Xu Juntao J Wang Hui H Zhu Jian J Zhu Jian J Zhuang Ting T
Neoplasia (New York, N.Y.) 20170105 2
The ubiquitin binding protein SHAPRIN is highly expressed in human breast cancer, one of the most frequent female malignancies worldwide. Here, we perform SHARPIN depletion in breast cancer cells together with RNA sequencing. The global expression profiling showed p53 signaling as a potential SHARPIN target. SHARPIN depletion decreased cell proliferation, which effect could be rescue by p53 knocking down. Depletion SHARPIN significantly increases p53 protein level and its target genes in multipl ...[more]
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