Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5219937 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.
Liu Yi Y Wang Guohao G Zhang Huimin H Ma Ying Y Lang Lixin L Jacobson Orit O Kiesewetter Dale O DO Zhu Lei L Gao Shi S Ma Qingjie Q Chen Xiaoyuan X
Bioconjugate chemistry 20151210 1
In the treatment of type 2 diabetes mellitus, it is very important to develop therapeutics with prolonged circulation half-life. Exendin-4 is a glucagon like peptide-1 receptor (GLP-1R) agonist that has been modified in different ways for imaging insulinoma and for treating type-2 diabetes. In this work, we synthesized a maleimide derivative of truncated Evans blue dye (MEB-C3-Mal) to conjugate with (Cys(40))exendin-4 to obtain a highly stable MEB-C3-(Cys(40))exendin-4 (denoted as Abextide II). ...[more]
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