Exendin-4-encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes.

ABSTRACT: Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics in DMNs is an efficacious approach; however, the importance of evaluating the activity of encapsulated compounds, during the fabrication process, has not been examined in detail. Conducting an analysis of thermal, chemical, and physical stress factors, including temperature, pH, and the interaction of the polymer and therapeutics mixture during preparation, is essential for retaining the activity of encapsulated therapeutics during and after fabrication. Here, we optimised the thermal, chemical, and physical parameters for the fabrication of exendin-4 (Ex-4)-encapsulated DMN

SUBMITTER: Fakhraei Lahiji S 

PROVIDER: S-EPMC5773556 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature