Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt CC
PROVIDER: S-EPMC5220280 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Schmitt Charlotte C CC Aranias Thomas T Viel Thomas T Chateau Danielle D Le Gall Maude M Waligora-Dupriet Anne-Judith AJ Melchior Chloé C Rouxel Ophélie O Kapel Nathalie N Gourcerol Guillaume G Tavitian Bertrand B Lehuen Agnès A Brot-Laroche Edith E Leturque Armelle A Serradas Patricia P Grosfeld Alexandra A
Molecular metabolism 20161104 1
<h4>Objective</h4>Intestinal glucose absorption is orchestrated by specialized glucose transporters such as SGLT1 and GLUT2. However, the role of GLUT2 in the regulation of glucose absorption remains to be fully elucidated.<h4>Methods</h4>We wanted to evaluate the role of GLUT2 on glucose absorption and glucose homeostasis after intestinal-specific deletion of GLUT2 in mice (GLUT2<sup>ΔIEC</sup> mice).<h4>Results</h4>As anticipated, intestinal GLUT2 deletion provoked glucose malabsorption as vis ...[more]