Ontology highlight
ABSTRACT:
SUBMITTER: Loza AJ
PROVIDER: S-EPMC5221580 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Loza Andrew J AJ Koride Sarita S Schimizzi Gregory V GV Li Bo B Sun Sean X SX Longmore Gregory D GD
Molecular biology of the cell 20160907 22
The mechanisms underlying collective migration are important for understanding development, wound healing, and tumor invasion. Here we focus on cell density to determine its role in collective migration. Our findings show that increasing cell density, as might be seen in cancer, transforms groups from broad collectives to small, narrow streams. Conversely, diminishing cell density, as might occur at a wound front, leads to large, broad collectives with a distinct leader-follower structure. Simul ...[more]