Ontology highlight
ABSTRACT:
SUBMITTER: Duellberg C
PROVIDER: S-EPMC5221588 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Duellberg Christian C Cade Nicholas Ian NI Surrey Thomas T
Molecular biology of the cell 20160803 22
Microtubules switch stochastically between phases of growth and shrinkage. The molecular mechanism responsible for the end of a growth phase, an event called catastrophe, is still not understood. The probability for a catastrophe to occur increases with microtubule age, putting constraints on the possible molecular mechanism of catastrophe induction. Here we used microfluidics-assisted fast tubulin washout experiments to induce microtubule depolymerization in a controlled manner at different tim ...[more]