Ontology highlight
ABSTRACT:
SUBMITTER: Franceschini L
PROVIDER: S-EPMC5221729 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Franceschini Lorenzo L Brouns Tine T Willems Kherim K Carlon Enrico E Maglia Giovanni G
ACS nano 20160815 9
Many important processes in biology involve the translocation of a biopolymer through a nanometer-scale pore. Moreover, the electrophoretic transport of DNA across nanopores is under intense investigation for single-molecule DNA sequencing and analysis. Here, we show that the precise patterning of the ClyA biological nanopore with positive charges is crucial to observe the electrophoretic translocation of DNA at physiological ionic strength. Surprisingly, the strongly electronegative 3.3 nm inte ...[more]