Ontology highlight
ABSTRACT:
SUBMITTER: He C
PROVIDER: S-EPMC5222606 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
He Chongsheng C Sidoli Simone S Warneford-Thomson Robert R Tatomer Deirdre C DC Wilusz Jeremy E JE Garcia Benjamin A BA Bonasio Roberto R
Molecular cell 20161001 2
Interactions between noncoding RNAs and chromatin proteins play important roles in gene regulation, but the molecular details of most of these interactions are unknown. Using protein-RNA photocrosslinking and mass spectrometry on embryonic stem cell nuclei, we identified and mapped, at peptide resolution, the RNA-binding regions in ∼800 known and previously unknown RNA-binding proteins, many of which are transcriptional regulators and chromatin modifiers. In addition to known RNA-binding motifs, ...[more]