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High resolution Raman spectroscopy mapping of stem cell micropatterns.


ABSTRACT: We report on the use of high resolution Raman spectroscopy mapping combined with a micro-engineered stem cell platform. This technique obtains quantitative information about the concentration of individual intracellular molecules such as proteins, lipids, and other metabolites, while tightly controlling cell shape and adhesion. This new quantitative analysis will prove highly relevant for in vitro drug screening applications and regenerative medicine.

SUBMITTER: von Erlach TC 

PROVIDER: S-EPMC5407440 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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High resolution Raman spectroscopy mapping of stem cell micropatterns.

von Erlach Thomas C TC   Hedegaard Martin A B MA   Stevens Molly M MM  

The Analyst 20150301 6


We report on the use of high resolution Raman spectroscopy mapping combined with a micro-engineered stem cell platform. This technique obtains quantitative information about the concentration of individual intracellular molecules such as proteins, lipids, and other metabolites, while tightly controlling cell shape and adhesion. This new quantitative analysis will prove highly relevant for in vitro drug screening applications and regenerative medicine. ...[more]

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