Ontology highlight
ABSTRACT:
SUBMITTER: Brooks JL
PROVIDER: S-EPMC5224347 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20161222 1
Palladium-catalyzed oxidative cyclization of alkenols provides a convenient entry into cyclic ethers but typically proceeds with little or no diastereoselectivity for cyclization of trisubstituted olefins to form tetrahydrofurans due to the similar energies of competing 5-membered transition-state conformations. Herein, a new variant of this reaction has been developed in which a PdCl<sub>2</sub>/1,4-benzoquinone catalyst system coupled with introduction of a hydrogen-bond acceptor in the substr ...[more]