Ontology highlight
ABSTRACT:
SUBMITTER: Najafova Z
PROVIDER: S-EPMC5224504 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20160919 1
Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. In this study we examined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is essential for osteoblast differentiation. Genome-wide analyses demonstrate that BRD4 is recruited to the transcriptional ...[more]