Ontology highlight
ABSTRACT:
SUBMITTER: Kumar N
PROVIDER: S-EPMC6432663 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kumar Namit N Tsai Yu-Hwai YH Chen Lei L Zhou Anbo A Banerjee Kushal K KK Saxena Madhurima M Huang Sha S Toke Natalie H NH Xing Jinchuan J Shivdasani Ramesh A RA Spence Jason R JR Verzi Michael P MP
Development (Cambridge, England) 20190301 5
Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual requirements across developmental time. Embryonic loss of CDX2 triggers homeotic transformation of intestinal fate, whereas adult-onset loss compromises crucial physiological functions but preserves intestinal identity. It is unclear how such diverse requirements are executed across the developmental continuum. Using primary and engineered human tissues, mouse genetics, and a multi-omics appro ...[more]