Ontology highlight
ABSTRACT:
SUBMITTER: Golia B
PROVIDER: S-EPMC5224513 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Golia Barbara B Moeller Giuliana Katharina GK Jankevicius Gytis G Schmidt Andreas A Hegele Anna A Preißer Julia J Tran Mai Ly ML Imhof Axel A Timinszky Gyula G
Nucleic acids research 20161007 1
ADP-ribosylation is a dynamic post-translation modification that regulates the early phase of various DNA repair pathways by recruiting repair factors to chromatin. ADP-ribosylation levels are defined by the activities of specific transferases and hydrolases. However, except for the transferase PARP1/ARDT1 little is known about regulation of these enzymes. We found that MacroD2, a mono-ADP-ribosylhydrolase, is exported from the nucleus upon DNA damage, and that this nuclear export is induced by ...[more]