Ontology highlight
ABSTRACT:
SUBMITTER: Wan G
PROVIDER: S-EPMC3796289 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Wan Guohui G Zhang Xinna X Langley Robert R RR Liu Yunhua Y Hu Xiaoxiao X Han Cecil C Peng Guang G Ellis Lee M LM Jones Stephen N SN Lu Xiongbin X
Cell reports 20130620 6
Expression of microRNAs (miRNAs) involves transcription of miRNA genes and maturation of the primary transcripts. Recent studies have shown that posttranscriptional processing of primary and precursor miRNAs is induced after DNA damage through regulatory RNA-binding proteins in the Drosha and Dicer complexes, such as DDX5 and KSRP. However, little is known about the regulation of nuclear export of pre-miRNAs in the DNA-damage response, a critical step in miRNA maturation. Here, we show that nucl ...[more]